Identifying Autism Susceptibility Genes
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چکیده
منابع مشابه
Identifying Autism Susceptibility Genes
stantial (36%–90%), whereas in dizygotic (DZ) pairs the rate is similar to the rate of autism among siblings of De Crespigny Park London, SE5 8AF affected children. Twin studies also suggest that the genetic predisposition extends to related, but milder, communication and/or social deficits. In the largest study (Bailey et al., 1995), 92% of MZ pairs were concor-Roosevelt Drive Oxford, OX3 7BN ...
متن کاملIdentifying autism loci and genes by tracing recent shared ancestry.
To find inherited causes of autism-spectrum disorders, we studied families in which parents share ancestors, enhancing the role of inherited factors. We mapped several loci, some containing large, inherited, homozygous deletions that are likely mutations. The largest deletions implicated genes, including PCDH10 (protocadherin 10) and DIA1 (deleted in autism1, or c3orf58), whose level of express...
متن کاملSearch for Susceptibility Genes in Autism Spectrum Disorders
Autism (MIM 209850) is a severe neurodevelopmental disorder characterized by abnormalities in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities, which are evident by the age of three years. Autism is the most severe form of a broad group of disorders known as pervasive developmental d...
متن کاملCandidate Genes for Inherited Autism Susceptibility in the Lebanese Population
Autism spectrum disorder (ASD) is characterized by ritualistic-repetitive behaviors and impaired verbal/non-verbal communication. Many ASD susceptibility genes implicated in neuronal pathways/brain development have been identified. The Lebanese population is ideal for uncovering recessive genes because of shared ancestry and a high rate of consanguineous marriages. Aims here are to analyze for ...
متن کاملMTHFR rs1801133 Gene Polymorphism and Autism Susceptibility
Background: It is believed that environmental and genetic factors may be responsible for autism. Methylenetetrahydrofolate reductase (MTHFR) and its gene polymorphisms have been shown to be implicated as risk factors in autism. Objectives: To analyze MTHFR C677T polymorphism (rs1801133) in autistic patients. Materials and Methods: This study was carried out in 2014 and 2015 in northern Ir...
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ژورنال
عنوان ژورنال: Neuron
سال: 2000
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)00081-7